Computational proteogenomic identification and functional interpretation of translated fusions and micro structural variations in cancer: Supplementary Materials
نویسندگان
چکیده
Yen-Yi Lin1,†, Alex Gawronski1,†, Faraz Hach1,3,†, Sujun Li, Ibrahim Numanagić, Iman Sarrafi, Swati Mishra, Andrew McPherson, Colin Collins, Milan Radovich, Haixu Tang, and S. Cenk Sahinalp School of Computing Science, Simon Fraser University, Burnaby, BC, Canada School of Informatics and Computing, Indiana University, Bloomington, IN, USA Vancouver Prostate Centre, Vancouver, BC, Canada Dept. of Urologic Sciences, University of British Columbia, Vancouver, BC, Canada Department of Surgery, Indiana University, School of Medicine, Indianapolis, IN, USA †The authors wish it to be known that the first three authors should be regarded as joint first authors. To whom the correspondence should be addressed
منابع مشابه
Functional Investigation of the Novel BRCA1variant (Glu1661Gly) byComputationalTools andYeastTranscription Activation Assay
Introduction: Mutations in the BRCA1 gene are major risk factors for breast and ovarian cancers. However, the relationship between some BRCA1 mutations and cancer risk remains largely unknown. Cancer risk predictions could be improved by evaluation of the impairment degree in the BRCA1 functions due to a specific mutation. This study aimed to assess the functional effect of a novel variant (Glu...
متن کاملFunctional Investigation of the Novel BRCA1variant (Glu1661Gly) byComputationalTools andYeastTranscription Activation Assay
Introduction: Mutations in the BRCA1 gene are major risk factors for breast and ovarian cancers. However, the relationship between some BRCA1 mutations and cancer risk remains largely unknown. Cancer risk predictions could be improved by evaluation of the impairment degree in the BRCA1 functions due to a specific mutation. This study aimed to assess the functional effect of a novel variant (Glu...
متن کاملSocrates: identification of genomic rearrangements in tumour genomes by re-aligning soft clipped reads
MOTIVATION Methods for detecting somatic genome rearrangements in tumours using next-generation sequencing are vital in cancer genomics. Available algorithms use one or more sources of evidence, such as read depth, paired-end reads or split reads to predict structural variants. However, the problem remains challenging due to the significant computational burden and high false-positive or false-...
متن کاملFunctional investigation of the BRCA1 Val1714Gly and Asp1733Gly variants by computational tools and yeast transcription activation assay
Mutations in the BRCA1 gene are known to be a major cause of hereditary breast cancer. However, characterizing the point mutationsassociated with cancer in BRCA1 is challenging because the functional impact of most of them is still unknown. Nowadays, a variety of methods are employed to identify cancer-associated mutations in BRCA1. This study is aimed to ass...
متن کاملComputational Identification of Micro RNAs and Their Transcript Target(s) in Field Mustard (Brassica rapa L.)
Background: Micro RNAs (miRNAs) are a pivotal part of non-protein-coding endogenous small RNA molecules that regulate the genes involved in plant growth and development, and respond to biotic and abiotic environmental stresses posttranscriptionally.Objective: In the present study, we report the results of a systemic search for identifi cation of new miRNAs in B. rapa using homology-based ...
متن کامل